Speaker Spotlight
He Wears a Glucose Monitor Onstage and Shows the Room What a Single Phone Call Does to a Leader’s Body.
Simon Luthi — Former Fortune 100 Chief Strategy Officer, JPMorgan Chase and American Express · Creator of Transmutation Design™ · Bestselling Author of Becoming the Rocket Shaman · Phoenix
Most keynotes about stress ask an audience to take the speaker’s word for it. Simon Luthi puts the evidence on the screen while it is happening.
Using a continuous glucose monitor, he shows a room in real time what stress does to the body. The line spikes from a phone call rather than from food. Then he demonstrates regulation and the line flattens. The point lands before he has finished explaining it.
His argument is that leadership failure in the AI era is often a biology problem rather than a strategy problem, and that executives are making high-stakes decisions while their nervous systems are fighting invisible tigers.
He Is Not Coming at This From Wellness
That distinction matters, because it determines whether a boardroom takes the material seriously.
Simon was a Chief Strategy Officer at JPMorgan Chase and American Express, and he helped scale Chase Travel roughly fivefold, from two billion to ten billion. He arrived at nervous system regulation from the operating side of a Fortune 100 company, not from a coaching practice, and a cancer diagnosis is what forced him to look at the biology underneath the performance.
For a CEO summit or a board retreat, that credential is the whole difference. The same content from someone without the operating background gets filed under wellness programming and skipped.
The Session With the Sharpest Premise
The Most Dangerous Leader in the Room is the one to look at for an executive audience, because it reframes something boards genuinely do not measure.
His claim is that the riskiest person in an organization is not the least experienced or least capable. It is the most dysregulated: the high performer who floods every room with the biochemical equivalent of an alarm going off, while believing they are at their best. Everyone has worked for that person, and nobody has ever seen it on a risk register.
The session makes the case for regulation as a measurable leadership competency rather than a personal wellness matter, backed by biomarker data. For a board retreat or a leadership summit willing to have an uncomfortable conversation, it is a strong and unusual choice.
Three Ways to Program Him
2026: The Year Humanity Upgrades Its Operating System is the flagship and the one built around the live glucose demonstration. It suits a conference general session or a kickoff where the agenda needs a moment people talk about afterward.
The Most Dangerous Leader in the Room is the executive session described above, for boards, C-suites and leadership summits.
Transmutation Design™: From Burned-Out to Brilliant is the practical one, walking through his three-phase method of Reveal, Recode and Regenerate, plus using HRV data as a nervous system dashboard. This is the pick for an organization that wants tools rather than a wake-up call.
His broader range spans AI-era leadership, decision-making under pressure, burnout prevention and organizational transformation. Full descriptions are on his speaker profile.
Book Simon Luthi
Available for keynotes on leadership in the AI era, executive decision-making under pressure, nervous system regulation and burnout prevention.