SIMON LUTHI
About Simon Luthi
Simon Luthi is a former Fortune 100 Chief Strategy Officer at JPMorgan Chase and American Express who is now a bestselling and award-winning author, keynote speaker, and creator of Transmutation Design™. After helping scale Chase Travel from $2 billion to $10 billion, a cancer diagnosis forced him to confront a truth most leaders ignore: in the AI era, leadership failure is often a biology problem, not a strategy problem.
Today, Simon helps executives stay healthy, sharp, and sovereign in a post-AI world by teaching leaders how to upgrade their human operating system. His work blends neuroscience, leadership, and personal transformation to help individuals and organizations perform at a higher level in an increasingly complex world.
Simon is the author of Becoming the Rocket Shaman, a #1 Amazon New Release and winner of Best Personal Transformation Book of 2025. He is also a global keynote speaker on neuroscience and leadership in the post-AI era and has been featured on CBS, FOX, NBC, and more than 100 media outlets.
Watch Simon Luthi In Action
Speaking Topics
How to Stay Healthy, Sharp, and Sovereign in a Post-AI Epoch
Every event planner building their 2026 agenda is asking the same question: what does leadership look like when AI is smarter than your executives?
This keynote answers that question and proves it live on stage.
Simon makes the case that the leaders who fail in the AI era will not fail because they lacked intelligence, strategy, or tools. They will fail because their nervous systems are stuck in chronic survival mode, making high-stakes decisions while their bodies fight invisible tigers.
Using a continuous glucose monitor demonstration, Simon shows audiences in real time what stress does to the body. Glucose spikes from a phone call, not a plate of food. Then he shows what happens when a leader learns to regulate. The line flattens. Decision-making sharpens. Presence transforms.
Part science demonstration. Part phoenix story. Part executive wake-up call.
Your body cannot tell the difference between a tiger and a Tuesday. This keynote proves it.
What Audiences Walk Away With
- Understanding of the invisible stress cascade destroying executive performance
- The neuroscience behind why AI-era leadership requires nervous system regulation
- Practical techniques to interrupt fight-or-flight before critical decisions
- A new framework for measuring leadership readiness through biomarkers
Why Dysregulation, Not Incompetence, Is the Hidden Risk No Board Is Measuring
Think about the most impressive leader you have ever worked for. The one who hit the biggest numbers, made the fastest decisions, and radiated pressure like a force of nature.
Now ask yourself how it felt to be in the room with that person.
The most dangerous leader in any organization is not the least experienced or the least intelligent. It is the most dysregulated. The one flooding every room with the biochemical equivalent of a five-alarm fire while believing they are performing at their best.
Simon draws on his journey from the C-suite to the cancer ward to the stage and makes the counterintuitive case that in a post-AI world, a leader's competitive advantage is no longer intelligence. It is their nervous system.
Backed by real biomarker data and delivered with the authority of someone who has lived both sides of this equation.
What Audiences Walk Away With
- A new definition of leadership risk beyond strategy and competence
- Understanding how dysregulated leaders create toxic environments invisibly
- The case for nervous system regulation as a measurable leadership competency
- Awareness that the AI era demands a fundamentally different kind of leader
The Science and Practice of Upgrading the Human Operating System
Most high performers are trying to run better apps on a phone that is overheating, out of storage, and running on three percent battery. No amount of productivity hacking, biohacking, or executive coaching will fix that. You do not need a better app. You need a new operating system.
Simon introduces Transmutation Design™, the three-phase methodology he developed after transforming from a burned-out Fortune 100 Chief Strategy Officer into a regulated, high-performing leader with biomarker data to prove it.
Audiences learn how to use HRV data to read their nervous system like a dashboard, how continuous glucose monitoring reveals invisible stress, and how the Rewrite Your Story™ process breaks patterns that keep leaders stuck.
This is the talk for organizations ready to move from awareness to action.
What Audiences Walk Away With
- The three-phase Transmutation Design™ framework: Reveal, Recode, Regenerate
- Practical nervous system regulation techniques for high-stakes moments
- How to measure leadership performance through biomarkers
- The Rewrite Your Story™ approach to breaking survival patterns
Featured In
Simon Luthi is featured on these Amplify Speakers lists
Speaker Spotlight: The Nervous System as Leadership Risk · Best Innovation & Entrepreneurship Keynote Speakers 2026 · Top AI Keynote Speakers to Watch in 2026 · Banking & Financial Services Speakers · Telecommunications Speakers · AI Keynote Speakers · CEO & C-Suite Keynote Speakers · Future of Work Speakers · Innovation & Entrepreneurship Speakers · Neuroscience & Brain-Based Performance Speakers · Technology & Digital Transformation Speakers